I recently try to submit a paper which deals with survival analysis using CMR-methods. In this paper I analysed the effect of a covariate on survival and compared it with models without the covariate. One concern of one of the reviewers was that the distribution of the covariate was not normal and therefore the analysis is not valid. The distribution of the covariate is more or less U-spaped, hence many animals do have values of 0 and 1 and the distribution of animals with values between zero and one have a normal distribution.


If so, is it valid to transform the covariate (but with an U-shaped distribution it is hardly possible to achieve a normal distribution by transformation, as far as I know).
Any comment would be very much appreciated, thanks in advance,
Bernd
p.s. From talking with statisticians I know that the distribution of the residuals from in a linear model should have a normal distribution. But how do I calculate the residuals from the model with the individual covariate. Do I calculate the survival of each indidivual and look at the distribution of these values?