David,
There are a variety of reasons why you could get nonsensical results from CMR data (as Dave pointed out). From your example above, your constant

and constant

model you show below gives what I would call an 'ok' SE on

. But, when you run a model with 8 additive effects (9 total parameters) for 40 data points, you are overparameterizing the model quite a bit, probably part of the nonsensical answers you are given. Are all those covariates supposed to be affecting

, or are some supposed to affect

. From your below, it looks like you have them all affecting

, correct? Also, you have variables that range from the 1000s to <10, so you might want to standardize your covariates, but I don't think that would help too much. As David suggested, have a look at Darryl's 2006 book, as well as the first few chapters in the MARKBOOK as it seems you need to better define your models in general. Also, do some searching on the phidot board on parameter estimability as that might help you out.
Bret