I am running an MSMR analysis on a dataset with 4 sites. At each site, the individuals can be any of several disease states (healthy thru severely diseased). I would like to evaluate the effect of environmental heterogeneity on both the survival and state-transition estimates. I have environmental data for each of the sites. There is no movement between sites, so I am treating 'site' as a fixed effect and I have environmental data for each site. Is this possible in ESURGE? The most recent manual (1.

only has an example for 1 site, and at that time, ANODEV was only possible for the first matrix in the 'transition' step. Has this been updated? If it is not possible in ESURGE, could I run this analysis in MARK? Thank you for your help.