Fitting homogeneous model when density is inhomogeneous

I have a question about potential bias for estimating abundance when fitting a homogeneous point process model to data generated by a non-uniform process. I will present 2 different examples. First, consider a situation where you are interested in realized abundance over a given region S (i.e., the state space) and design a study that places detectors evenly and throughout a region R that coincides with S (R = S). In simulations where the distribution of individual across the landscape was patchy, Efford and Fewster (2013) found that a homogeneous Poisson model could estimate N without substantial bias. For the second example, consider density is inhomogeneous, R is represented by an array of detector clusters and is a subset of S, and a homogeneous model is used. Am I correct stating that the potential bias of the estimate of realized N in this case would be very sensitive to the distribution of clusters? I assume that clusters would need to be stratified by ‘local’ differences in density if a homogeneous model was fitted because misrepresentation of areas with different densities in the sample would result in a biased estimate of the point intensity parameter which would bias an estimate of N for the entire region S. Obviously, explicitly modeling spatial variation in density as a function of landscape variables believed to be driving density would be preferred. However, I’m just trying to understand all the consequences of not having that information available and having to fit a homogeneous model.
Thanks
Jared
Thanks
Jared