Spatial indepedence and covariate/buffer intersection (edit)

Hi folks,
[*]Edit. Maybe the best way to ask this is as such: Are there statistical constraints in terms of building a use/non-use or presence/absence model based upon a moving window of explanatory covariates? In other words, can two units consider portions of the same "patch" if the specific surrounding configuration of the landscape differs (or, can explanatory buffers around detection stations have some overlap/spatial intersection and be considered truly independent?)
Cheers,
John
[*]Edit. Maybe the best way to ask this is as such: Are there statistical constraints in terms of building a use/non-use or presence/absence model based upon a moving window of explanatory covariates? In other words, can two units consider portions of the same "patch" if the specific surrounding configuration of the landscape differs (or, can explanatory buffers around detection stations have some overlap/spatial intersection and be considered truly independent?)
Cheers,
John